Latest Publications:
Aguiar-Pulido V, Wolujewicz P, Martinez-Fundichely A, Elhaik E, Thareja G, Abdel Aleem A, Chalhoub N, Cuykendall T, Al-Zamer J, Lei Y, El-Bashir H, Musser JM, Al-Kaabi A, Shaw GM, Khurana E, Suhre K, Mason CE, Elemento O, Finnell RH, Ross ME. Systems biology analysis of human genomes points to key pathways conferring spina bifida risk. Proc Natl Acad Sci U S A. 2021 Dec 21;118(51):e2106844118. doi: 10.1073/pnas.2106844118. PMID: 34916285; PMCID: PMC8713748.
Wolujewicz P, Steele JW, Kaltschmidt JA, Finnell RH, Ross ME. Unraveling the complex genetics of neural tube defects: From biological models to human genomics and back. Genesis. 2021 Nov;59(11):e23459. doi: 10.1002/dvg.23459. Epub 2021 Oct 29. PMID: 34713546.
Abdel Fattah AR, Daza B, Rustandi G, Berrocal-Rubio MÁ, Gorissen B, Poovathingal S, Davie K, Barrasa-Fano J, Cóndor M, Cao X, Rosenzweig DH, Lei Y, Finnell R, Verfaillie C, Sampaolesi M, Dedecker P, Van Oosterwyck H, Aerts S, Ranga A. Actuation enhances patterning in human neural tube organoids. Nat Commun. 2021 May 27;12(1):3192. doi: 10.1038/s41467-021-22952-0. PMID: 34045434; PMCID: PMC8159931.
Finnell RH, Caiaffa CD, Kim SE, Lei Y, Steele J, Cao X, Tukeman G, Lin YL, Cabrera RM, Wlodarczyk BJ. Gene Environment Interactions in the Etiology of Neural Tube Defects. Front Genet. 2021 May 10;12:659612. doi: 10.3389/fgene.2021.659612. PMID: 34040637; PMCID: PMC8143787.
Copp AJ, Greene NDE, Jao J, Zash R, Mohan H, Dontsova V, Serghides L. Dolutegravir and rat whole embryo culture. Birth Defects Res. 2022 Jan 1;114(1):23-24. doi: 10.1002/bdr2.1969. Epub 2021 Dec 1. PMID: 34851540.
Nychyk O, Galea GL, Molè M, Savery D, Greene NDE, Stanier P, Copp AJ. Vangl2-environment interaction causes severe neural tube defects, without abnormal neuroepithelial convergent extension. Dis Model Mech. 2022 Jan 1;15(1):dmm049194. doi: 10.1242/dmm.049194. Epub 2022 Jan 26. PMID: 34842271; PMCID: PMC8807581.
Galea GL, Maniou E, Edwards TJ, Marshall AR, Ampartzidis I, Greene NDE, Copp AJ. Cell non-autonomy amplifies disruption of neurulation by mosaic Vangl2 deletion in mice. Nat Commun. 2021 Feb 19;12(1):1159. doi: 10.1038/s41467-021-21372-4. Erratum in: Nat Commun. 2021 May 28;12(1):3301. PMID: 33608529; PMCID: PMC7895924.
Leung KY, De Castro SCP, Galea GL, Copp AJ, Greene NDE. Glycine Cleavage System H Protein Is Essential for Embryonic Viability, Implying Additional Function Beyond the Glycine Cleavage System. Front Genet. 2021 Jan 25;12:625120. doi: 10.3389/fgene.2021.625120. PMID: 33569080; PMCID: PMC7868403.
D'Souza SW, Copp AJ, Greene NDE, Glazier JD. Maternal Inositol Status and Neural Tube Defects: A Role for the Human Yolk Sac in Embryonic Inositol Delivery? Adv Nutr. 2021 Feb 1;12(1):212-222. doi: 10.1093/advances/nmaa100. PMID: 32892218; PMCID: PMC7849949.
Zhou Y, Crider KS, Yeung LF, Rose CE, Li Z, Berry RJ, Li S, Moore CA. Periconceptional folic acid use prevents both rare and common neural tube defects in China. Birth Defects Res. 2022 Jan 31. doi: 10.1002/bdr2.1983. Epub ahead of print. PMID: 35098705.
Wilson RD, O'Connor DL. Maternal folic acid and multivitamin supplementation: International clinical evidence with considerations for the prevention of folate-sensitive birth defects. Prev Med Rep. 2021 Oct 25;24:101617. doi: 10.1016/j.pmedr.2021.101617. PMID: 34976673; PMCID: PMC8684027.
Fabelo C, He H, Lim FY, Atzinger C, Wong B. Factors impacting surgical decision making between prenatal and postnatal repair for myelomeningocele. Prenat Diagn. 2022 Jan;42(1):27-36. doi: 10.1002/pd.6080. Epub 2021 Dec 20. PMID: 34931327.
Hansen JM, Lucas SM, Ramos CD, Green EJ, Nuttall DJ, Clark DS, Marchant ED, Hancock CR, Piorczynski TB. Valproic acid promotes SOD2 acetylation: a potential mechanism of valproic acid-induced oxidative stress in developing systems. Free Radic Res. 2022 Jan 19:1-15. doi: 10.1080/10715762.2021.2017913. Epub ahead of print. PMID: 34895005.
Previous Publications:
Wallingford JB, Niswander LA, Shaw GM, Finnell RH. The continuing challenge of understanding, preventing, and treating neural tube defects. Science. 2013 Mar 1;339(6123):1222002. doi: 10.1126/science.1222002. PMID: 23449594
Andrew J Copp, Philip Stanier, Nicholas DE Greene. Neural tube defects: recent advances, unsolved questions, and controversies. The Lancet Neurology. Volume 12, Issue 8, Aug 2013, 799–810.